His Grace Bishop Demetrios (Kantzavelos) of Mokissos, a native of Chicago born to first-generation Greek-Americans, Merope (nee Kossivas) and the late Christ J. Kantzavelos, grew up as an active participant in the life of the city's historic Assumption Greek Orthodox Community located at 601 S. Central Avenue. He went on to attend Hellenic College and Holy Cross School of Theology in Brookline, Massachusetts, where he obtained his graduate divinity degree 'with high distinction' in 1987. Following graduation, he pursued post-graduate work in the doctoral philosophy program of Chicago's Loyola University, concentrating in the area of metaphysics.

Having received monastic tonsure, Bishop Demetrios was ordained to the Diaconate October of 1989. In 1992, he was ordained to the priesthood, and in 1995 elevated to the rank of Archimandrite, all through the hands of Metropolitan Iakovos of Chicago. Since then, he has served as assistant and deacon to the bishop, as associate pastor of Annunciation Cathedral of Chicago, and presently as Chancellor of the Metropolis of Chicago.

Named as "one of the twelve people to watch" by The Chicago Sun-Times (January 5, 2003), Bishop Demetrios has worked extensively to build bridges of understanding and improve relationships between Chicago's Greek Orthodox Community with other local Orthodox bodies, as well as other Christian and non-Christian groups. His ecumenical and interfaith commitments are numerous, coalescing around areas of social justice and advocacy. To this end, in February of 2003, he co-founded a local initiative to improve relations between the Turkish and Greek communities in Chicago.

In 1992, Bishop Demetrios established the Bishop's Task Force on AIDS, the first formal Orthodox Christian response to this pandemic in the western hemisphere. As this ministry received widespread recognition, its founder-coordinator Bishop Demetrios was named Outstanding Community Leader by the Cook County Board of Commissioners in 1995, and received the Jim Noone Award for Religious Leadership from the AIDS Pastoral Care Network in 1997. The Task Force has since become a resource for the entire Greek Orthodox Archdiocese of America. From 2001 until 2004, he served as board member of Chicago's Alexian Brothers' Bonaventure House, a premiere residential care facility for people living with HIV/AIDS. In August of 2005, Bishop Demetrios was honored with the Alexian Brothers AIDS Ministry 2005 President's Award.

Name day: October 26

Members of the Holy Eparchial Synod

His Eminence Archbishop Elpidophoros of America

Consecration date: March 1, 2011
Name day: November 2

His Eminence Metropolitan Methodios of Boston

Consecration date: April 8, 1984
Name day: June 14

His Eminence Metropolitan Alexios of Atlanta

Consecration date: May 17, 1987
Name day: March 17

His Eminence Metropolitan Nicholas of Detroit

Consecration date: April 3, 1999
Name day: December 6

His Eminence Metropolitan Savas of Pittsburgh

Consecration date: February 2, 2002
Name day: December 5

His Eminence Metropolitan Gerasimos of San Francisco

Consecration date: February 9, 2002
Name day: October 20

His Eminence Metropolitan Apostolos of New Jersey

Consecration date: December 20, 2014
Name day: June 30

His Eminence Metropolitan Nathanael of Chicago

Consecration date: March 17, 2018
Name day: June 11
Auxiliary Bishops

His Grace Bishop Demetrios of Mokissos

Greek Orthodox Archdiocese of America
Consecration date: December 9, 2006
Name day: October 26

His Grace Bishop Sevastianos of Zela

Greek Orthodox Archdiocese of America
Consecration date: December 6, 2011
Name day: December 18

His Grace Bishop Joachim of Amissos

Greek Orthodox Archdiocese of America
Consecration date: December 22, 2019
Name day: September 9

His Grace Bishop Spyridon of Amastris

Greek Orthodox Archdiocese of America
Consecration date: November 14, 2020
Name day: December 12

His Grace Bishop Timothy of Hexamilion

Greek Orthodox Archdiocese of America
Consecration date: December 5, 2020
Name day: January 22

His Grace Bishop Ioannis of Phocaea

Greek Orthodox Archdiocese of America
Consecration date: December 19, 2020
Name day: January 7

His Grace Athenagoras of Nazianzos

Greek Orthodox Archdiocese of America
Consecration date: June 5, 2021
Name day: July 24

His Grace Bishop Constantine of Sassima

Greek Orthodox Archdiocese of America
Consecration date: October 15, 2022
Name day: May 21
Former Archbishops

His Eminence Spyridon

Greek Orthodox Archdiocese of America
Consecration date: November 5, 1985
Name day: December 12

His Eminence Demetrios

Consecration date: September 17, 1967
Name day: October 26
Retired Bishops

His Eminence Metropolitan Isaiah of Denver

Consecration date: May 25, 1986
Name day: May 9

His Eminence Metropolitan Dimitrios of Xanthos

Greek Orthodox Archdiocese of America
Consecration date: May 31, 1998
Name day: October 26

His Grace Bishop Andonios of Phasiane

Greek Orthodox Archdiocese of America
Consecration date: February 23, 2002
Name day: January 17
Metropolises & Hierarchs